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Accordingly, an overproduction of PYY in transgenic mouse models reduced bone mass, whereas PYY knockout mice displayed increased bone mass and strength (54), although the opposite was shown in a study with another PYY knockout model (55)

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However, this also makes it challenging to distinguish whether GLP-1RAs exert their effects by directly regulating immune cells or indirectly improving metabolic parameters

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Short half-life GLP-1 drugs can have short half-lives, which may limit their efficacy even with frequent dosing