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It is widely distributed throughout the body, being expressed on vascular endothelial cells, T lymphocytes, the gastrointestinal tract, hepatobiliary system, kidneys, and pulmonary tract (61, 62)

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Once activated, Akt phosphorylates tuberous sclerosis complex 2 (TSC2), suppressing the inhibitory effect of the TSC1-TSC2 complex in mTORC1

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