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Intraperitoneal (i.p.) injections of 6 mmol kg 1 BSO or 14 mg kg 1 iAs dissolved in a 0.9% saline solution or 0.9% saline solution alone were administered to mice

Although this study primarily focuses on the mechanisms by which ESC modulates sphingolipid metabolism through reshaping the gut microbiome, it is noteworthy that ESC might also affect sphingolipid metabolism through other pathways

These reagents support two clinically relevant concepts: (1) Combination sensitization: FSP1 blockade can sensitize tumors to upstream ferroptosis-inducing nodes (for example, GPX4 inhibition or cystine import disruption), consistent with the idea that tumors rely on redundant antioxidant systems

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