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The loss of PDG-1b contributes to decreased respiration in VHL-deficient renal carcinoma cells

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Additional protective measures include: Regular foot examinations (at least annually, more frequently for high-risk patients) and proper foot care to prevent complications Daily self-inspection of feet for injuries, redness, or changes Maintaining healthy lifestyle habits: balanced diet, regular exercise, avoiding excessive alcohol Managing cardiovascular risk factors (blood pressure, lipids) that contribute to nerve damage Avoiding other medications that may worsen neuropathy when possible For patients with painful diabetic neuropathy, evidence-based treatments include duloxetine, pregabalin, gabapentin, and tricyclic antidepressants