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Verspohl EJ: Novel therapeutics for type 2 diabetes: Incretin hormone mimetics (glucagon-like peptide-1 receptor agonists) and dipeptidyl peptidase-4 inhibitors

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Studies tracking radiolabeled peptide demonstrate metabolism primarily in plasma, with resulting amino acids entering normal metabolic pathways

It is designed to sequentially target multiple metabolic pathways simultaneously, which can aid obesity, liver health, and cardiac risks

Activated PGC-1 subsequently activates nuclear respiratory factor 1 (NRF-1) and NRF-2, thereby stimulating the expression of related factors such as mitochondrial transcription factor A (TFAM)

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