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Serious Side Effects Serious side effects of Pepto-Bismol can occur, though they are rare: Bowel blockage : This can occur due to Pepto-Bismol-related constipation and is a particular concern in adults 65 and older

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For example, UK SmPCs for GLP-1 receptor agonists advise caution in patients with a history of pancreatitis or gallbladder disease, and include precautionary guidance regarding thyroid symptoms (such as a neck mass, difficulty swallowing, or hoarseness) that should be reported promptly

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However, studies show that mental impairment related to low B12 levels can improve with B12 treatment