When can GLP-1 drugs make sense
Association Between Gastrointestinal AEs of Interest and PROs (SURPASS-2) Across all PRO measures in the SURPASS-2 study, changes from baseline to week 40 were in the direction of better outcomes in both subgroups of patients who did and did not report gastrointestinal AEs (nausea, vomiting or diarrhoea) and all treatment groups (tirzepatide 5, 10 or 15 mg or semaglutide 1 mg) (Fig
Triple agonism (GLP-1 + GIP + glucagon) is a real mechanistic advance, not just marketing but the full implications, especially for muscle mass, aren't confirmed yet
(7) Dietary protein As the three precursors and foundation of glutathione production are amino acids, dietary protein intake may influence the amino acid pool that glutathione synthesis draws on (8)
[16] Lauritano E, Bilotta A, Gabrielli M et al
The four-week minimum at each dose exists for good reason