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Typical lipid changes with GLP-1 therapy include: Total cholesterol reduction: 28% LDL cholesterol reduction: 36% Triglyceride reduction: 1015% HDL cholesterol: minimal change or slight increase These effects vary by agent, dose, population, and treatment duration, as shown in systematic reviews and meta-analyses

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[3] [4] Regular follow-up allows early identification and management of adverse effects, optimizing both safety and treatment adherence

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Preclinical studies further suggest that GLP-1RAs may modulate key cytokine pathways implicated in psoriatic disease, including NF-B, IL-6, IL17, and IL23, while small clinical studies have reported improvements in skin disease severity in PsO (37)

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