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The anti-inflammatory effects may be both direct and indirect
Whether such GLP-1 derived fragments are relevant for the GLP-1-induced liver autophagy induction is not known and required further investigation
These diverse effects are mediated through multiple molecular mechanisms, including metabolic regulation, direct antitumor activities, immunomodulation, and epigenetic modifications
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Long-term NSAID use can cause gastrointestinal bleeding, cardiovascular events, and kidney impairment
Early Discoveries, With More to Come So far, GLP-1s, first approved 20 years ago for type 2 diabetes and later obesity, have shown potential in treating a surprisingly wide range of conditions, such as heart disease, Parkinsons, Alzheimers, sleep apnea, and liver disease
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