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A recent small review study of patients with autism treated with varying doses of NAC presented no adverse effects and a reduction in social irritability

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Patients with G6PD deficiencies cannot metabolize high levels of IV vitamin C, which is why blood work is vital to consider before administering high-dose vitamin C

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Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H (2011) Role of proinflammatory cytokines in the pathophysiology of osteoarthritis