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Under normal conditions, CI regenerates the reducing equivalent NADH to NAD + (Supplementary Fig

Through substrate competition between iNOS and Arg1, arginine couples inflammatory NO production with polyamine/reparative metabolic branches, thereby regulating the balance between pro-inflammatory cytotoxicity and tissue repair within the same substrate framework ( Taking TCA cycle reprogramming as an example, pro-inflammatory activation is often accompanied by TCA cycle disruption and the accumulation of signaling intermediates, among which succinate has been shown to promote IL-1 production and amplify inflammatory responses through HIF-1 (132)

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Clinically TMAO is a very significant molecule that plays a crucial role in determining the risk and even early manifestations of certain conditions

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[PMID: 6743340] PubMed record related to this compound for laboratory literature review