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5 Therapeutic potential of IGF-1-R targeting in cancer 5.1 IGF-1R silencing can abrogate cancer drug resistance in vitro It appears from the data presented above that IGF-1-R signaling targeting could be an excellent therapeutic strategy in cancer, particularly in chemotherapy resistant cases ( Figure 4 )
FIGURE 3 FIGURE 4 (B ) Initial presentation of the persistent gastrocutaneous fistula and BPC 157 therapy effect
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This structural modification also reduces its binding affinity to IGF binding proteins, allowing it to remain bioactive in circulation significantly longer than endogenous IGF-1
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