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Jansen R, et al

Indian Journal of Dermatology, Venereology and Leprology, 83, 9

The majority of GLP-1s are produced by L-cells lining the small intestine and colon

The liver contains GLP-1 receptors, and activation appears to directly reduce hepatic lipogenesis (fat production in the liver), increase fatty acid oxidation, and reduce inflammatory signaling in hepatocytes

Interesting findings, Amr El-Refaey

Our data predict a balanced, highly favourable effective binding enthalpy profile of our newly designed peptides for the three receptors compared to endogenous peptides and the experimental reference peptides, with high targeted specificity for the receptors