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NF-B activation, NLRP3 inflammasome assembly, and production of TNF-, IL-1, nitric oxide, ROS, and complement proteins all contribute to synaptic dysfunction, disrupt mitochondrial dynamics, and increase dopaminergic neuron death

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CoQ10 also helps improve insulin resistance and regulate blood sugar levels in people with diabetes

(General reference on nasal bioavailability and molecular weight thresholds.) Merkus FW, Verhoef JC, Schipper NG, Marttin E