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With the progression of liver diseases, cells are persistently stimulated by external factors (such as oxidative stress, pathogens) or internal factors (such as hormonal fluctuations or iron overload), the basal autophagy levels changes, thereby modifying the cell's susceptibility to ferroptosis

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Gallstone-related bowel obstruction (ileus) also requires urgent medical treatment with surgical stone removal and repair of the intestinal wall, and sometimes cholecystectomy either as part of the same procedure or later (Turner 2018)