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The primary endpoint of weight loss of at least 5% occurred in 85% of the tirzepatide 5 mg group, 89% of the tirzepatide 10 mg group and 91% of participants in the tirzepatide 15 mg group

We showed that inherent anxiety at baseline and elevated expression of the mineralocorticoid receptors (MR) in the hippocampus predisposes to a stress-induced suppression of expression of metabotropic glutamate receptors-2 (mGlu2, a key inhibitor of spontaneous glutamate release) with development of depressive-like behavior via epigenetic mechanisms of histone acetylation [20]

These side effects may range from mild to serious

A MASLD substudy within the phase 2 obesity trial of retatrutide provided compelling evidence of hepatic benefits

Benzoyl peroxide May increase dryness or irritation