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The manufacturer (EMD Serono) voluntarily discontinued Geref in 2008 for commercial reasons, not due to safety concerns
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We understand that making sustainable changes requires more than just medication
have demonstrated that butyrate contributes to epithelial barrier tightness through the inhibition of iron-dependent prolyl hydroxylase enzymes, leading to the stabilization of hypoxia-inducible factor (HIF) (Ornelas et al., 2023)
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