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November 8, 2023 (obesity, as Zepbound) Starting switch dose / 2.5 mg tirzepatide weekly, regardless of prior semaglutide dose Typical washout / None strictly required
It is not a drug, dietary supplement, food, or cosmetic and has not been approved by the U.S
Many patients find morning administration preferable, as this allows any mild gastrointestinal effects to occur during waking hours
How to Use Glutagem Take 2 capsules in the morning and 2 capsules at night after meals
Acronyms A1C - Hemoglobin A1C ADA - American Diabetes Association CVD - Cardiovascular disease DM - Diabetes mellitus FBS - Fasting blood sugar GFR - Glomerular filtration rate GI - Gastrointestinal GLP-1 - Glucagon-like peptide-1 OSA - Obstructive sleep apnea RCT - Randomized controlled trial T2DM - Type 2 diabetes mellitus Thyroid C-cell tumor = Thyroid medullary tumor DRUGS IN CLASS Dual GLP-1 and GIP agonists Tirzepatide (Mounjaro) - marketed for diabetes Tirzepatide (Zepbound) - marketed for weight loss MECHANISM OF ACTION GLP-1 and GIP GLP-1 stands for "glucagon-like peptide-1," and GIP stands for "glucose-dependent insulinotropic polypeptide." GIP is also sometimes referred to as "gastric inhibitory polypeptide." GLP-1 and GIP are hormones secreted by specialized cells in the small intestine in response to food consumption
Focus on sterile technique and consistent depth (subcutaneous, not intramuscular) rather than site selection
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