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Furthermore, the improvements in glucose homeostasis following prebiotic treatment are dependent on GLP-1R signaling, implicating that prebiotic-induced alterations in the microbiome restore the gutbrain axis 257

Immune peptides function as modulators, steering inflammation either up or down as necessary

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Other regulatory factors, such as bile acids, can stimulate the release of GLP-1 and PYY by activating the TGR5 receptor on the surface of intestinal L cells (3537)