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To exclude the possibility that GSH is cleaved by enzymes to release glutamate for Ca signal propagation, we employed GGsTop, a well-known chemical inhibitor that specifically targets gamma-glutamyl transpeptidase (GGT), the enzyme responsible for converting GSH to Glu 26

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Experimental approachescompound information Atpenin A5 (Cat# sc-202475A) and scyllo-inositol (Cat# sc-202808) were obtained from Santa Cruz Biotechnology (Dallas, Texas, USA) and dissolved in DMSO for atpenin A5 and in HPLC water for scyllo-inositol

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