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Insulin Sensitivity and Blood Glucose Retatrutide's triple mechanism improves glycemic control through multiple pathways: GLP-1 activity stimulates glucose-dependent insulin secretion and suppresses glucagon when blood sugar is high GIP activity enhances insulin sensitivity in adipose tissue and improves nutrient partitioning Glucagon activity paradoxically improves hepatic insulin sensitivity by reducing liver fat and improving hepatic glucose metabolism In the phase 2 type 2 diabetes trial, participants achieved HbA1c reductions of up to 2.02% bringing many into the normal glycemic range
Most commonly, GLP-1 drugs are administered daily or weekly via an injection into a fatty part of the bodythink belly, thighs, or back of the armbut some also come in tablet form to be ingested
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Liver Enlargement and Hepatotoxicity Both enzyme induction and proliferation of endoplasmic reticulum are responses that enhance metabolism and detoxification
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