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Retatrutide adds glucagon receptor activation, which plays a role in fat breakdown and energy expenditure
It is FDA-cleared to improve the appearance of cellulite and skin laxity on the upper arms, and may also be used to address concerns on areas such as the abdomen, legs, and buttocks
Animal studies demonstrate that GLP-1 receptor agonists reduce dopamine signaling in this pathway
But the doses required (typically 5001,500 mg of berberine per day) are far beyond what a small patch can plausibly deliver through the skin, even before you account for the absorption barrier
RS: Methodology, Writing review & editing
GLP-1 is a leading class of medicine for diabetes that will lose patent protection from FY26 (India, Canada) to FY30 (the US)
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