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Whatever the underlying genetic cause that leads to iron overload, clinical manifestations and organ damage depend on the amount and the rate of iron accumulation in tissues and the different capacity of cells and tissues to cope with the iron-induced oxidative damage

Oral administration of NAD + precursors, such as tryptophan, nicotinic acid (niacin), nicotinamide, and nicotinamide riboside (NR), could increase tissue NAD + levels 525,526

& Immenschuh, S

Sayin VI, Ibrahim MX, Larsson E, Nilsson JA, Lindahl P, Bergo MO

However, in the real world this isnt always possible