It is worth noting that for currently licensed GLP-1 receptor agonists in the UK, the thyroid tumour signal is classified as a precautionary consideration based on rodent data, rather than a formal contraindication as reflected in UK Summaries of Product Characteristics (SmPCs)
Notably, the reductions observed in these parameters were greater than those seen with semaglutide 1 mg, another GLP-1 receptor agonist, in the SUPRASS-2 trial.Tirzepatide was generally well-tolerated, with a low risk of hypoglycaemia when used without insulin or insulin secretagogues
Clin Chem 40 : 857858
Vascularity increases dramatically
To complicate matters further, the gene for cystathionine -synthase is also on chromosome 21 (21q22.3)
Molecular Structure Peptide Sequence: GlyHisLys Complex: GHK coordinated with Cu Molecular Formula (GHKCu): CHCuNO Molecular Weight: 340.88 g/mol Peptide Class: Copperbinding tripeptide Form: Lyophilized powder, researchgrade The copper complex adopts a squareplanar coordination geometry involving the histidine imidazole and terminal amine groups