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Concentrations reported in published preclinical animal studies vary widely by model, route, and endpoint, and they are not dosing recommendations

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doi: 10.1517/13543784.2010.513381 109 PorterDWIrwinNIFlattPRHlscherCGaultVA

Glucagon is also involved in acutely regulating glucose homeostasis and administration of pharmacological doses of glucagon in animal models for diabetes or obesity has demonstrated regulatory effects on lipid metabolism, energy expenditure, and food intake ( The GLP-1/glucagon agonist cotadutide (MEDI0382) is the compound of this dual-receptor agonist class that is the most advanced in clinical development