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Fertility of male or female rats was unaffected by metformin when administered at doses as high as 600 mg/kg/day, which is approximately 3-times the maximum recommended human dose based on body surface area comparisons

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Expert Rev Clin Pharmacol 14:10391050 El-Tanbouly DM, Wadie W, Sayed RH (2017) Modulation of TGF-/Smad and ERK signaling pathways mediates the anti-fibrotic effect of mirtazapine in mice

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