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Adding therapies that modify the tumor environment may enhance outcomes

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Together with yeast and cancer data showing transcription coupled eccDNA formation at highly expressed loci and rapid dosage shifts under selection, these observations argue that eccDNA formation is an interesting route by which stressed cells explore increased gene copy number and novel regulatory contexts without committing to irreversible chromosomal rearrangements ( Seen through this lens, eccDNA mediated gene amplification represents a conditionally directed response: stress exposure does not necessarily target amplification at specific loci, but biases eccDNA formation and retention toward genomic regions that are both transcriptionally active and functionally beneficial under the prevailing conditions

While the literature extensively describes the ideal multidisciplinary management of PWS [9], few case reports detail the challenges of implementing this care when a diagnosis is made after severe complications have occurred [10, 11]

Despite its common use in many Asian countries as a skin lightening agent, efficacy in skin lightening of IV glutathione remains unclear due to the lack of human clinical trials evaluating the efficacy

E., Cragen, L