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Using fatty acids to prolong the duration of the action of peptides and proteins was already a long established technique at Novo Nordisk and elsewhere and had been successfully applied to insulin (insulin detemir) (Knudsen, Lau)
Compounded GLP-1 medications are subject to evolving FDA policy
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PMID: 32858949 Tomas FM, Knowles SE, Owens PC, Read LC, Chandler CS, Gargosky SE, Ballard FJ
Most GI symptoms are significantly milder than they were during the 4mg and 8mg escalation phases, even though the absolute dose is higher
The post stresses these policies change frequently
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