Therefore, the author proposed, could rapid normalization of the cardiometabolic system by GLP-1 RAs be the cause rather than a direct adverse effect of the drug? The commentary adds that further biological plausibility should be considered: GLP-1 receptors are known to be expressed throughout the retina, within retinal ganglion cells, and within the central nervous system, the author wrote
A., Toulmay, A
Studies like the recent Diabetes Care (ADA, Jan 2026) publication remind us that our role isnt to create fear, but to explain absolute risk, acknowledge uncertainty, and balance it against the well-established cardiovascular, renal, metabolic, and mortality benefits of GLP-1based therapies
Instead of using a rigid percentage, this calculator adjusts carbohydrates based on your calorie intake, protein target, and fat needs while maintaining a minimum intake for daily function and energy levels
Ipamorelin acts on this system