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How the carnitine shuttle works: Long-chain fatty acids cannot efficiently enter the mitochondrial matrix on their own

The switch exhibits tunable, robust, and reversible kinetics of transgene expression

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Compared to the liver, we observed that the kidney has: (1) similar increased use of energy-related metabolites and production of urea cycle and ammonia-related intermediates, suggesting a shared catabolism in AKI, and (2) higher pools of energy metabolism intermediates in AKI

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