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These effects translate to improved tensile strength and elasticity in connective tissue and vasculature, while also supporting visible improvements in skin firmness, density, and texture

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2020 Nov;91(11):1201-1209

It was also established that besides MSU crystals alone, macrophages engulfing MSU crystals and creating granulomas could further spur the generation of M1 macrophage polarization, intensifying interstitial inflammation and propagating chronic kidney disease (CKD) progression (72)

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Colonoscopy scheduled. Follow up