A similar modification was performed in albiglutide
Yiannopoulou KG, Papageorgiou SG
The results showed that liraglutide had a modest positive effect on improving motor function and performed well in terms of safety and tolerability, although there were some manageable gastrointestinal side effects.432 The study emphasizes the need for further research into the potential benefits and risks of liraglutide in patients at different stages of PD.432 GLP-1RAs and addictive disorders Researchers have discovered that semaglutide has the ability to reduce both recurrent alcohol consumption and overall alcohol intake in rats by more than 50%.433 Specifically, alcohol-dependent rats were administered semaglutide, which resulted in a significant reduction in their alcohol consumption.433 Further investigation into the mechanism underlying the alcohol-reducing effects of semaglutide suggested that this effect may involve the modulation of alcohol-induced rewards and punishments within the brain

This may reflect the effect higher doses of chemotherapeutic agents given in the second trial
48 Wu C, Yang F, Zhong H, Hong J, Lin H, Zong M, Ren H, Zhao S, Chen Y, Shi Z, et al
The glutathione in this supplement is a highly pure and stable form of the compound designed in a fermentation process