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Since there are obvious differences between rodent and human physiology, it cannot be ignored that this may have a significant impact on the efficacy and safety of (any) novel agents
However, the 91.6% response rate and 6-month durability in a knee pain population that presumably included treatment-resistant cases is a signal
Administration preference influences adherence
I mean, if there's any impact, and there is at least one preliminary study that glutathione is increased in the brain after humans are basically taking sulforaphane
Many researchers notice effects within 24 weeks of daily use
Any important protocol modification such as changes to eligibility criteria, outcome analyses will be thoroughly communicated with DSMB members and will obtain amendment clearance from the institutional review board (IRB)
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