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In acute myeloid leukemia (AML), wild-type (WT) BCAT 1 can metabolize hydrogen peroxide (H2O2), while CXXC motif mutants (CXXS) and wild-type (WT) BCAT 2 cannot

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However, when mitochondrial membranes are depolarized, the dye fails to form red aggregates

We have therefore necessarily made a number of assumptions about the loss of GSH, GSSG, Cys, Gly, and Glu to other tissues