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It was investigated as a candidate obesity therapeutic but did not meet its primary endpoints in clinical trials, and no marketing approval followed

Protas EJ, Mitchell K, Williams A, Qureshy H, Caroline K, Lai EC

Alcohol abuse, aging, smoking, diabetes, thyroid disorders, medications such as antacids and Type 2 Diabetes medications as well as gastric bypass surgery can all affect your absorption levels

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Clinical and Experimental Metastasis

NNMT (nicotinamide N-methyltransferase) is an enzyme that methylates nicotinamide, draining methyl donors and reducing NAD+ salvage