"When the vein is overworked from having to push blood up the body against gravity, the valves seals become leaky and blood is allowed to go backward, leading to the vein becoming enlarged." This explains why varicose veins almost always occur on the legs because when we're standing or sitting, our veins have to work against gravity to do their job
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Neville ML, Chan C, Barnett BR, Hernandez RE, Moore CE, Figueroa JS (2023) Three-coordinate monoanions of rhodium(1-) and iridium(1-): isolable examples of coordinatively-unsaturated metalate anions
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