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"Constipation from GLP-1s can be compounded by the fact that people are eating less," says Hamilton, "resulting often in less fiber consumption and less stool bulk overall." Many people also drink less fluid to avoid feeling overly full on GLP-1 medications, which can also lead to constipation

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Unfortunately, this can result in poor outcomes for patients who have to deal with ongoing pain, discomfort, and follow-up procedures

GLP-1 medications may cause side effects including nausea, vomiting, diarrhea, constipation, and abdominal pain

Faster initial weight loss may reflect water loss or aggressive calorie restriction, which can be difficult to maintain