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doi: 10.1111/dom.16298 21

Exenatide and lixisenatide are primarily cleared through the kidneys, while liraglutide, dulaglutide, semaglutide, and tirzepatide undergo proteolytic degradation throughout the body with minimal renal excretion of intact drug

This helps prevent cross-contamination and ensures a controlled environment

This means we're desensitized to it, which can lead to type 2 diabetes, cardiovascular disease, metabolic syndrome and more

186 The pronounced lack of renal reabsorption of filtered urate in hypouricemic patients with GLUT9 loss-of-function mutations provides compelling evidence of the critical role this protein plays in renal tubular urate reabsorption

Yla-Herttuala, S