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The liver has no GLP-1 or GIP receptors but is rich in glucagon receptors, which makes retatrutide an attractive option in the nephrology community
The FDA does require a boxed warning for GLP-1 receptor agonists (Wegovy, Saxenda) and the dual GIP/GLP-1 receptor agonist tirzepatide (Zepbound) regarding thyroid C-cell tumors, based on rodent studies, though human relevance remains uncertain
You also learn which strategies work best for promoting successful lifestyle changes
It is currently in clinical trials as a treatment option for adults with type 2 diabetes (T2DM) and obesity
Confirmation of ingredient quality and quantity of unregulated supplements can be difficult
It helps alleviate insulin resistance as well as obesity induced by a high-fat diet
