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Glucagon-like peptide-1 cleavage product GLP-1(9-36) reduces neuroinflammation from stroke via the activation of insulin-like growth factor 1 receptor in astrocytes
doi: 10.3389/fphar.2022.909408 20 WangYWangCXiaMTianZZhouJBergerJ
Austin, P
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In this trial, 56 patients with vascular cognitive impairment, who were already taking donepezil (Aricept) were given either 1,500 mg ALC per day or placebo for 28 weeks
Initially developed for type 2 diabetes, GLP-1RAs have demonstrated robust weight loss in randomized controlled trials and real-world settings, leading to their repositioning as cornerstone obesity treatments ( Human metabolic studies consistently show that reductions in energy intake account for most of the weight loss observed during GLP-1RA therapy, whereas increases in resting energy expenditure are modest or absent ( Beyond total weight loss, the quality of weight loss has become an increasingly important clinical concern
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