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Unlike semaglutide (GLP-1 only) or tirzepatide (GLP-1 + GIP), Retatrutide adds glucagon receptor agonism, making it a triple agonist with distinct pharmacological properties under study
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found that signal transducers and activators of transcription 3 (STAT3) promote MYC expression in tumor cells in AML, which in turn regulates the transcription of amino acid transporter SLC1A5, promotes Gln metabolism in AML cells, and oxidative phosphorylation (OXPHOS) of leukemia stem cells (LSCs)
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