People on the maximum dose lost an average of 85 lb after 104 weeks, or slightly more than 30 percent of their starting body weight
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A key function of GLP-1 is to lower blood sugar levels, achieved through stimulating insulin production by the pancreas in response to high blood sugar, and inhibiting glucagon secretion, which otherwise raises blood sugar levels by promoting glucose production in the liver
Effects on energy expenditure have been observed in early-phase and preclinical work, but this finding requires confirmation in larger trials
With off-label use, doctors prescribe a drug for a purpose other than what its approved for
The evidence supporting GLP-1 medications for weight loss and metabolic health is robust