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Clinical assessment Clinical assessment was done using modified Hemi-Melasma Area and Severity Index (HEMI-MASI) to grade the severity of melasma before and after stoppage of treatment by two blinded independent dermatologists
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Whereas it is unlikely that the topical preparation as such immediately and directly reaches the hair bulb region, it has been shown that drug delivery to the skin occurs also through the hair follicles [32]
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