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Investigating local administration through phase 1 safety and pharmacokinetic trials is a critical first step to bypass the BRB and maximize retinal tissue exposure while minimizing systemic side effects
The complex is then transported into the mitochondrial matrix by carnitine palmitoyltransferase I (CPT I) and carnitine palmitoyltransferase II (CPT II)
The trade-off is that benzyl alcohol is an additional chemical variable, and for some proteins a documented aggregation risk
Normally, mTOR is activated in the background of high levels of nutrients and energy substrates [257, 258]
Protein intake matters too
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