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For most nano-phytomedicines, an optimal hydrodynamic diameter of 50150 nm balances circulation time, endothelial uptake, and diffusion within the brain parenchyma, which is why SLNs, NLCs, PLGA NPs, and liposomes designed for CNS targeting typically fall within this range (118)

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Lack of Zn can impair these enzymes capacity to fix damaged DNA, which can accelerate the onset of cancer (105)

J Biol Chem 272 : 1000410012

Its not surprising, then, that you feel the effects if you dont have enough glutathione in your system