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How reactive metabolites induce an immune response that sometimes leads to an idiosyncratic drug reaction
Bettelheim P, Valent P, Andreeff M , Tafuri A, Haimi J, Gorischek C, Muhm M, Ch S, Haas O, Vieder L, Schulz G, Speiser W, Geissler K, Kier P, Hinterberger W, Lechner K
Cancers need for glutamine is so great that some cancer-causing oncogenes alter how much of it the cells take up and digest
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Similarly, Staphylococcus aureus -toxin and phenol-soluble modulins perturb mitochondrial function, amplifying tissue destruction during severe infections such as pneumonia and sepsis ( 3.2 Bacterial manipulation of mitochondrial dynamics Mitochondrial fission and fusion processes, orchestrated by DRP1, MFN1/2, and OPA1, represent key checkpoints in cellular homeostasis
(19) "These findings show, for the first time, that daily consumption of GSH supplements was effective at increasing body compartment stores of GSH"- Study authors
