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demonstrated that exogenous IGF-1 administration reduces functional deficits and accelerates recovery in a rat Achilles tendon injury model ( In vitro studies further support its therapeutic potential, showing that IGF-1 modulates inflammatory responses, stimulates tenocyte proliferation and migration, and enhances collagen synthesis ( 2 Materials and methods Approximately 90% of the papers mentioned in this review (total number of papers included in this review: 103) were found by a search in the Web of Science/Google Scholar databases using the keywords tendon injury, IGF-1, tendon regenerative healing, tendon repair, tenocyte, mechanisms (the search was performed during the period of May to September 2024 and only literature written in English was reviewed) (Figure 1)