slc25a39 is necessary for mitochondrial glutathione import in mammalian cells Autoregulatory control of homeostasis slc25a39 glutathione how does enter

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Trends Endocrinol Metab 31(6):422434

This process, along with GCL inhibition and the formation of mixed disulfides between GSH and protein sulfhydryl, concurred to a steady-state decrement of free GSH concentration and, consequently, to an intracellular redox state shift toward more oxidizing conditions, which could be required for avoiding fast reduction of oxidized cysteines allowing the upstream ROS-induced autophagic stimulus to be propagated

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Thiol-based redox switches in eukaryotic proteins