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This is important because many patients with alcohol use disorder (AUD) abuse other substances and suffer from fatty liver and other metabolic abnormalities

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Dose adjustments are built into the treatment planthough scheduling should be individualized based on tolerability, side effects, contraindications, and clinical responseand they get routed through the same shared messaging thread

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The importance of vagal sensory neurons was further demonstrated by Hwang and colleagues, who showed that loss of this liver-brain axis prevented diet-induce obesity, increased energy expenditure and improved glucose homeostasis in mice [44]