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Ipamorelin's structure emerged from a different optimization strategyremoval of the central dipeptide from GHRP-1 combined with Aib N-terminal substitutionresulting in a pentapeptide with potency comparable to hexapeptide GHRPs but with fundamentally different selectivity

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So we look at the totality of the circumstances and the underlying action

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8,14,16,33 Research is beginning to support use of these clinical options in ME/CFS and/or long COVID, but additional real-world studies and randomized control trials in ME/CFS are greatly needed